Treatment With CRH-1 Antagonist Antalarmin Reduces Beiiavioral and Endocrine Responses to Social Stressors in Marmosets {Callithrix kuhlii)
نویسندگان
چکیده
JEFFREY A. FRENCH^"^*, JEFFREY E. FITE^'^, HEATHER JENSEN\ KATIE OPAROWSKI^'^, MICHAEL R. RUKSTALIS^'^, HOLLY FIX^ ^ BRENDA JONES^'^, HEATHER MAXWELL^-^, MOLLY PACER^-^, MICHAEL L. POWER* ^ AND JAY SCHULKIN"-'' ^ Callitrichid Research Center, University of Nebraska at Omaha, Omaha, Nebraska ^Department of Psychology, University of Nebraska at Omaha, Omaha, Nebraska ^Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska ''Research Department, American College of Obstetrics and Gynecology, Washington, DC ^Department of Conservation Biology, Smithsonian National Zoological Park, Washington, DC ^Department of Physiology and Biophysics, Georgetown University, Washington, DC
منابع مشابه
Treatment with CRH-1 antagonist antalarmin reduces behavioral and endocrine responses to social stressors in marmosets (Callithrix kuhlii).
Corticotropin-releasing hormone (CRH) has multiple roles in coordinating the behavioral and endocrine responses to a host of environmental challenges, including social stressors. In the present study we evaluated the role of CRH in mediating responses to a moderate social stressor in Wied's black tufted-eared marmosets (Callithrix kuhlii). Male and female marmosets (n=14) were administered anta...
متن کاملThe impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.
The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it's potential activity in blunting behavioral and endocrine sequelae of stressor exposure has not been assessed. Because antagonism of central CRH by alpha-helical CRH attenuates conditioned fear responses, we sought to test antalarmin in this regard. In addition, it remain...
متن کاملOral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates.
We evaluated the effects of the lipophilic nonpeptide corticotropin-releasing hormone (CRH) type 1 receptor antagonist antalarmin on the behavioral, neuroendocrine, and autonomic components of the stress response in adult male rhesus macaques. After oral administration, significant antalarmin concentrations were detected in the systemic circulation and the cerebrospinal fluid by a mass spectrom...
متن کاملBehavioral responses to social separation stressor change across development and are dynamically related to HPA activity in marmosets.
Psychosocial stressors activate two distinct stress-response systems, a central, behavioral response, and a peripheral, endocrine response. Both behavioral and endocrine responses to stressors are subject to individual and developmental variables, but it is not known whether stressor induced behaviors are stable across development, and how they correspond with changes in the endocrine component...
متن کاملProduction and perception of sex differences in vocalizations of Wied's black-tufted-ear marmosets (Callithrix kuhlii).
Males and females from many species produce distinct acoustic variations of functionally identical call types. Social behavior may be primed by sex-specific variation in acoustic features of calls. We present a series of acoustic analyses and playback experiments as methods for investigating this subject. Acoustic parameters of phee calls produced by Wied's black-tufted-ear marmosets (Callithri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008